Aging Changes in Voltage-Gated Calcium Currents in Hippocampal CA1 Neurons

@article{Campbell1996AgingCI,
  title={Aging Changes in Voltage-Gated Calcium Currents in Hippocampal CA1 Neurons},
  author={Luke W. Campbell and S Y Hao and Olivier Thibault and Eric M. Blalock and Philip W. Landfield},
  journal={The Journal of Neuroscience},
  year={1996},
  volume={16},
  pages={6286 - 6295}
}
  • Luke W. Campbell, S Y Hao, +2 authors Philip W. Landfield
  • Published 1996
  • Biology, Medicine
  • The Journal of Neuroscience
  • Previous current-clamp studies in rat hippocampal slice CA1 neurons have found aging-related increases in long-lasting calcium (Ca)-dependent and Ca-mediated potentials. These changes could reflect an increase in Ca influx through voltage-gated Ca channels but also could reflect a change in potassium currents. Moreover, if altered Ca influx is involved, it is unclear whether it arises from generally increased Ca channel activity, lower threshold, or reduced inactivation. To analyze the basis… CONTINUE READING

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    Potassium currents in hippocampal pyramidal cells.

    Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons

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