Aging: a shift from redox regulation to oxidative damage.

@article{Humphries2006AgingAS,
  title={Aging: a shift from redox regulation to oxidative damage.},
  author={Kenneth M Humphries and Pamela A. Szweda and Luke I. Szweda},
  journal={Free radical research},
  year={2006},
  volume={40 12},
  pages={
          1239-43
        }
}
Proteins, nucleic acids, and lipids can undergo various forms of oxidative modification. In numerous instances, these modifications result in irreversible loss of function. The age-dependent accumulation of oxidatively modified and dysfunctional macromolecules provides the basis for the free radical theory of aging. Pro-oxidants, however, are also capable of catalyzing fully reversible modifications to protein. It is increasingly apparent that these reactions participate in redox-dependent… CONTINUE READING
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