Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

  title={Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.},
  author={Augusto Orlandi and Marie-Luce Bochaton-Piallat and Giulio Gabbiani and Luigi Giusto Spagnoli},
  volume={188 2},
Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogenetic risk factor, intimately associated to other parietal, microenvironmental and systemic noxae. Smooth muscle cells (SMCs) represent the major arterial cell population. As aging… CONTINUE READING
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