Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system.

@article{Dilger2008AgingMC,
  title={Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system.},
  author={Ryan N Dilger and Rodney W Johnson},
  journal={Journal of leukocyte biology},
  year={2008},
  volume={84 4},
  pages={932-9}
}
Recent studies suggest that activation of the peripheral immune system elicits a discordant central (i.e., in the brain) inflammatory response in aged but otherwise healthy subjects compared with younger cohorts. A fundamental difference in the reactive state of microglial cells in the aged brain has been suggested as the basis for this discordant inflammatory response. Thus, the aging process appears to serve as a "priming" stimulus for microglia, and upon secondary stimulation with a… CONTINUE READING
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