Aging, cellular senescence, and cancer.

@article{Campisi2013AgingCS,
  title={Aging, cellular senescence, and cancer.},
  author={Judith Campisi},
  journal={Annual review of physiology},
  year={2013},
  volume={75},
  pages={685-705}
}
For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function. However, especially among vertebrates, aging also promotes hyperplastic pathologies, the most deadly of which is cancer. In contrast to the loss of function that characterizes degenerating cells and tissues, malignant (cancerous) cells must acquire new (albeit aberrant) functions that allow them to develop into a lethal tumor. This review discusses… CONTINUE READING
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