Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.

@article{Curcio2009AgingAM,
  title={Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.},
  author={Christine A. Curcio and Mark W. Johnson and J Huang and Martin Rudolf},
  journal={Progress in retinal and eye research},
  year={2009},
  volume={28 6},
  pages={393-422}
}
The largest risk factor for age-related macular degeneration (ARMD) is advanced age. A prominent age-related change in the human retina is the accumulation of histochemically detectable neutral lipid in normal Bruch's membrane (BrM) throughout adulthood. This change has the potential to have a major impact on physiology of the retinal pigment epithelium (RPE). It occurs in the same compartment as drusen and basal linear deposit, the pathognomonic extracellular, lipid-containing lesions of ARMD… CONTINUE READING

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Aging and Bruch’s membrane

  • J. Marshall, A. A. Hussain, C. Starita, D. J. Moore, A. L. Patmore
  • 1998
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