Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks

@article{Hardeland2019AgingMA,
  title={Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks},
  author={R. Hardeland},
  journal={International Journal of Molecular Sciences},
  year={2019},
  volume={20}
}
  • R. Hardeland
  • Published 2019
  • Chemistry, Medicine
  • International Journal of Molecular Sciences
Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity. In non-tumor cells, several effects of melatonin are abolished by inhibiting SIRT1, indicating mediation by SIRT1. Melatonin is, in addition to its circadian and antioxidant roles, an immune stimulatory agent. However, it can act as either a pro- or anti-inflammatory regulator… Expand
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