Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon

@inproceedings{Clark2009AggressivenessOH,
  title={Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon},
  author={Emily S. Clark and Brandee T. Brown and Amy S. Whigham and Avtandyl Kochaishvili and Wendell G. Yarbrough and Alissa M. Weaver},
  booktitle={Oncogene},
  year={2009}
}
11q13 amplification is a late-stage event in several cancers that is often associated with poor prognosis. Among 11q13-amplified genes, the actin assembly protein cortactin/CTTN is considered a likely candidate for direct involvement in tumor progression because of its cell motility-enhancing functions. We modulated cortactin expression in head and neck squamous cell carcinoma (HNSCC) cell lines. Cortactin expression levels directly correlated with tumor size, vascularization and cell… CONTINUE READING
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