Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?

@inproceedings{ElShamy2016AggressivenessNC,
  title={Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?},
  author={Wael M ElShamy and Abhilasha Sinha and Neveen Said},
  booktitle={Stem cells international},
  year={2016}
}
The relationship between tumor initiation and tumor progression can follow a linear projection in which all tumor cells are equally endowed with the ability to progress into metastasis. Alternatively, not all tumor cells are equal genetically and/or epigenetically, and only few cells are induced to become metastatic tumor cells. The location of these cells within the tumor can also impact the fate of these cells. The most inner core of a tumor where an elevated pressure of adverse conditions… CONTINUE READING