Aggressive variants of castration-resistant prostate cancer.

  title={Aggressive variants of castration-resistant prostate cancer.},
  author={Himisha Beltran and Scott Arthur Tomlins and Albert Aparicio and Vivek K Arora and David S. Rickman and Gustavo Ayala and Jiaoti Huang and Lawrence D. True and Martin E. Gleave and Howard R. Soule and Christopher J. Logothetis and Mark A. Rubin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={20 11},
A subset of patients with advanced castration-resistant prostate cancer may eventually evolve into an androgen receptor (AR)-independent phenotype, with a clinical picture associated with the development of rapidly progressive disease involving visceral sites and hormone refractoriness, often in the setting of a low or modestly rising serum prostate-specific antigen level. Biopsies performed in such patients may vary, ranging from poorly differentiated carcinomas to mixed adenocarcinoma-small… CONTINUE READING


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