Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria.

@article{Valent2003AggressiveSM,
  title={Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria.},
  author={Peter Valent and Cem Akin and Wolfgang R Sperr and Lorena Escribano and Michel Arock and Hans Paul Horny and J. Michael Bennett and Dean D Metcalfe},
  journal={Leukemia research},
  year={2003},
  volume={27 7},
  pages={
          635-41
        }
}
Aggressive systemic mastocytosis (ASM) is a clonal mast cell disease characterized by progressive growth of neoplastic cells in diverse organs leading to organopathy. The organ-systems most frequently affected are the bone marrow, skeletal system, liver, spleen, and the gastrointestinal tract. Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function and ascites, and… CONTINUE READING
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