Aggressive sporadic histiocytic sarcoma with immunoglobulin heavy chain gene rearrangement and t(14;18).

@article{Hayase2010AggressiveSH,
  title={Aggressive sporadic histiocytic sarcoma with immunoglobulin heavy chain gene rearrangement and t(14;18).},
  author={Eiko Hayase and Mitsutoshi Kurosawa and Masakatsu Yonezumi and Sachiko Y Suzuki and Hiroaki Suzuki},
  journal={International journal of hematology},
  year={2010},
  volume={92 4},
  pages={659-63}
}
Histiocytic sarcoma (HS) is a rare but aggressive malignant neoplasm of histiocytic lineage with a poor prognosis. Immunohistochemically, the neoplastic cells are positive for CD163, CD68, and lysozyme, and negative for B and T cell markers. However, molecular studies on the origin of the neoplastic cells remain inconclusive. A 54-year-old woman was admitted to our hospital because of painful swelling of the left knee. Examination revealed generalized lymphadenopathy and splenomegaly. HS was… CONTINUE READING