Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.

@article{Linde2012AggressiveCP,
  title={Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.},
  author={Denise van der Linde and Ingrid van de Laar and Aida M. Bertoli-Avella and Rogier A. Oldenburg and Jos Bekkers and Francesco U. S. Mattace-Raso and Anton H. van den Meiracker and Adriaan Moelker and Fop van Kooten and Ingrid M E Frohn-Mulder and Janneke Timmermans and Els Moltzer and Jan Maarten Cobben and Lut Van Laer and Bart Loeys and Julie De Backer and Paul J Coucke and Anne De Paepe and Yvonne Hilhorst-Hofstee and Marja W. Wessels and Jolien W Roos-Hesselink},
  journal={Journal of the American College of Cardiology},
  year={2012},
  volume={60 5},
  pages={397-403}
}
OBJECTIVES The purpose of this study was describe the cardiovascular phenotype of the aneurysms-osteoarthritis syndrome (AOS) and to provide clinical recommendations. BACKGROUND AOS, caused by pathogenic SMAD3 variants, is a recently described autosomal dominant syndrome characterized by aneurysms and arterial tortuosity in combination with osteoarthritis. METHODS AOS patients in participating centers underwent extensive cardiovascular evaluation, including imaging, arterial stiffness… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 10 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…