Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8.

@article{Montani2013AggressiveBA,
  title={Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8.},
  author={Giorgia Montani and Simone Tonelli and Valentina Sanghez and Pier Francesco Ferrari and Paola Palanza and Andreas Zimmer and Roberto Tirindelli},
  journal={The Journal of physiology},
  year={2013},
  volume={591 16},
  pages={3949-62}
}
Heterotrimeric G-proteins are critical players in the transduction mechanisms underlying odorant and pheromonal signalling. In the vomeronasal organ (VNO) of the adult mouse, two different G-protein complexes have been identified. Gαoβ2γ8 is preferentially expressed in the basal neurons and coexpresses with type-2 vomeronasal pheromone receptors (V2Rs) whereas Gαi2β2γ2 is found in the apical neurons and coexpresses with type-1 vomeronasal pheromone receptors (V1Rs). V2R-expressing neurons… CONTINUE READING