Aggressive behavior increases after termination of chronic sildenafil treatment in mice.

@article{Hotchkiss2005AggressiveBI,
  title={Aggressive behavior increases after termination of chronic sildenafil treatment in mice.},
  author={Andrew K. Hotchkiss and Leah M. Pyter and Michelle L Gatien and Jarvi C Wen and Harry A Milman and Randy J Nelson},
  journal={Physiology & behavior},
  year={2005},
  volume={83 5},
  pages={683-8}
}
Recent reports to the U.S. Food and Drug Administration Adverse Event Reporting System implicate sildenafil citrate in adverse emotional and aggressive behaviors. Sildenafil citrate (Viagra) is widely prescribed for erectile dysfunction and acts by inhibiting phosphodiesterase Type-5, resulting in accumulation of cyclic-guanosine monophosphate (cGMP). Cyclic-GMP is synthesized by guanylyl cyclase that is directly activated by the messenger molecule, nitric oxide (NO), formed throughout the CNS… CONTINUE READING

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