Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.

@article{Strous2003AggressiveBI,
  title={Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.},
  author={Rael David Strous and Karen Ann Nolan and Raya Lapidus and Libna Diaz and Takuya Saito and Herbert M. Lachman},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2003},
  volume={120B 1},
  pages={29-34}
}
We have previously reported that increased aggressive behavior in schizophrenic patients may be associated with a polymorphism at codon 158 of the catechol O-methyltransferase (COMT) gene that encodes a low enzyme activity variant. The finding has been replicated by one group, but not others. The discordant findings could be due to statistical errors or methodological issues in the assessment of aggressive/violent behavior. Consequently, additional studies are needed. Patients with… CONTINUE READING

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