Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up

@article{Roggen2004AggressiveAA,
  title={Aggressive angiomyxoma: a clinicopathological and immunohistochemical study of 11 cases with long-term follow-up},
  author={J. Frans Graadt van Roggen and J. A. M. van Unnik and Inge H. Briaire-de Bruijn and P. C. W. Hogendoorn},
  journal={Virchows Archiv},
  year={2004},
  volume={446},
  pages={157-163}
}
To report the clinicopathological and immunohistochemical features and longer term biological behaviour of aggressive angiomyxoma, an uncommon mesenchymal neoplasm occurring predominantly in the pelvi-perineal region of adults. Using immunohistochemistry, possible overexpression of CDK4 and MDM2 was analysed, which might point to (cyto)genetic alteration(s) in chromosome region 12q13–15, an area reported to be altered in this tumour entity. Cases (n=11) of aggressive angiomyxoma were retrieved… CONTINUE READING
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