Aggressive Surgical Resection for Hilar-invasive and Peripheral Intrahepatic Cholangiocarcinoma

@article{Nakagohri2003AggressiveSR,
  title={Aggressive Surgical Resection for Hilar-invasive and Peripheral Intrahepatic Cholangiocarcinoma},
  author={Toshio Nakagohri and Takehide Asano and Hirotoshi Kinoshita and Takashi Kenmochi and Tetsuro Urashima and Fumihiko Miura and Takenori Ochiai},
  journal={World Journal of Surgery},
  year={2003},
  volume={27},
  pages={289-293}
}
The clinicopathology and surgical outcome of intrahepatic cholangiocarcinomas are not fully understood. The objective of this study was to clarify the clinicopathologic features of intrahepatic cholangiocarcinoma and evaluate prognostic factors influencing survival. Forty consecutive patients with intrahepatic cholangiocarcinomas undergoing surgical resection at Chiba University Hospital between October 1981 and October 1997 were analyzed retrospectively. Intrahepatic cholangiocarcinomas were… 

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The extent of lymphadenectomy does not seem to have influence on the survival of patients with HBV-associated ICC, and routine lymph node dissection is not recommended, particularly for those without lymph node metastasis.

Initial Presentation and Management of Hilar and Peripheral Cholangiocarcinoma: Is a Node-Positive Status or Potential Margin-Positive Result a Contraindication to Resection?

Given the lack of effective alternative therapy, when confronted with the potential risk of positive margins or isolated nodal disease, the author continues to advocate aggressive surgical resection for both hilar and peripheral CC with the ultimate goal of negative margin resection.
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