Aggressive Surgical Resection for Hilar-invasive and Peripheral Intrahepatic Cholangiocarcinoma

  title={Aggressive Surgical Resection for Hilar-invasive and Peripheral Intrahepatic Cholangiocarcinoma},
  author={Toshio Nakagohri and Takehide Asano and Hirotoshi Kinoshita and Takashi Kenmochi and Tetsuro Urashima and Fumihiko Miura and Takenori Ochiai},
  journal={World Journal of Surgery},
The clinicopathology and surgical outcome of intrahepatic cholangiocarcinomas are not fully understood. The objective of this study was to clarify the clinicopathologic features of intrahepatic cholangiocarcinoma and evaluate prognostic factors influencing survival. Forty consecutive patients with intrahepatic cholangiocarcinomas undergoing surgical resection at Chiba University Hospital between October 1981 and October 1997 were analyzed retrospectively. Intrahepatic cholangiocarcinomas were… 

Surgical Outcome and Prognostic Factors in Intrahepatic Cholangiocarcinoma

Investigation of patients with intrahepatic cholangiocarcinoma who underwent surgical resection at the National Cancer Center Hospital East between October 1992 and July 2007 found that intra hepatic metastasis was the strongest predictor of poor survival.

Prognostic Factors After Surgical Resection for Intrahepatic, Hilar, and Distal Cholangiocarcinoma

R0 resection and adjuvant chemotherapy may be mandatory to achieve long-term survival for patients with cholangiocarcinoma.

Survival Analysis of Intrahepatic Cholangiocarcinoma After Resection

Preoperative CA19-9 level was a valuable clinical factor for predicting histopathologic invasiveness as well as clinical outcome and an adequate resection margin was the only modifiable factor by a surgeon during hepatic resection for ICC.

Intrahepatic Cholangiocarcinoma: Clinicopathological Differences Between Peripheral Type and Hilar Type

Clinicopathological characteristics are almost similar between patients with PICC and HICC, and Nodal involvement is a potent prognostic factor for patients with ICC.

Retrospective Analysis of Histopathologic Prognostic Factors After Hepatectomy for Intrahepatic Cholangiocarcinoma

The histopathologic characteristics of intrahepatic metastasis were closely related to poor prognosis in ICC patients, and extensive hepatectomy with LN dissection may offer the only chance for long-term survival in patients with ICC.

Prediction of the Postoperative Prognosis of Intrahepatic Cholangiocarcinoma (ICC): Importance of Preoperatively-Determined Anatomic Invasion Level and Number of Tumors

Preoperatively diagnosed hilar invasion, multiple intrahepatic tumors and histologically confirmed lymph node metastasis were the main determinants of an adverse postoperative prognosis in patients with ICC.

Perineural Invasion Is a Prognostic Factor in Intrahepatic Cholangiocarcinoma

Perineural invasion is frequently found in patients with ICC and is an independent prognostic factor, which potentially has a role as a determinant of patient selection for adjuvant therapy.

The role of lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma: A review.

  • C. SpositoM. Droz dit Busset V. Mazzaferro
  • Medicine
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2021

Prognosis after resection for hepatitis B virus-associated intrahepatic cholangiocarcinoma.

The extent of lymphadenectomy does not seem to have influence on the survival of patients with HBV-associated ICC, and routine lymph node dissection is not recommended, particularly for those without lymph node metastasis.

Initial Presentation and Management of Hilar and Peripheral Cholangiocarcinoma: Is a Node-Positive Status or Potential Margin-Positive Result a Contraindication to Resection?

Given the lack of effective alternative therapy, when confronted with the potential risk of positive margins or isolated nodal disease, the author continues to advocate aggressive surgical resection for both hilar and peripheral CC with the ultimate goal of negative margin resection.



Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan.

By selecting patients based on the biological characteristics of the tumor and taking into account patients' quality of life, complete surgical resection can be performed safely and is associated with long-term survival.

Liver resection for hilar and peripheral cholangiocarcinomas: a study of 62 cases.

Even though rare, 5-year survival by resection can be achieved in both HCCA and PCCA, but new adjuvant treatments are clearly needed.

Extended resection for intrahepatic cholangiocarcinoma in Japan.

It is concluded that extended surgery does not improve the curative resection rate or the surgical outcome of ICC, and that extended Surgery is not indicated for patients with infiltrating-spread type tumors.

Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma.

This is the first reported study on the effectiveness of liver resection for the treatment of mass-forming type cholangiocarcinoma, showing that surgical therapy can prolong survival if local radicality can be achieved and lymph-node metastases are absent.

Macroscopic classification and preoperative diagnosis of intrahepatic cholangiocarcinoma in Japan.

The macroscopic classification of ICC is useful for preoperative diagnosis of tumor extent and for planning the surgical procedure, and percutaneous transhepatic cholangioscopy provided the most reliable information for designing the operative procedure.

Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors.

Cholangiocarcinoma is best classified into three broad groups: 1) intrahepatic, 2) perihilar, and 3) distal tumors, which correlate with anatomic distribution and imply preferred treatment.

Intrahepatic cholangiocarcinoma in Taiwan.

Concomitant hepatolithiasis prevented precise diagnosis preoperatively and precipitated biliary sepsis, which affected resectability and increased postoperative morbidity.

Lymphatic spreading pattern of intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinomas, irrespective of their intrahepatics location, mainly spread to the nodes in the hepatoduodenal ligament, then to the para-aortic node, retropancreatic nodes, or common hepatic artery nodes.