Aggression Escalated by Social Instigation or by Discontinuation of Reinforcement (“Frustration”) in Mice: Inhibition by Anpirtoline: A 5-HT1B Receptor Agonist

@article{Almeida2002AggressionEB,
  title={Aggression Escalated by Social Instigation or by Discontinuation of Reinforcement (“Frustration”) in Mice: Inhibition by Anpirtoline: A 5-HT1B Receptor Agonist},
  author={Rosa Maria Martins de Almeida and Klaus A. Miczek},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={27},
  pages={171-181}
}

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References

SHOWING 1-10 OF 71 REFERENCES

Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253

The hypothesis that activation of 5-HT1B receptors modulates very high levels of aggressive behavior in a pharmacologically and behaviorally specific manner is supported.

Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists

The hypothesized significant role of 5-HT1A receptors in the aggression-heightening effects of alcohol is supported, with results suggesting behavioral specificity of these anti-aggressive effects.

Oral drug self-administration in the home cage of mice: alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline

The effective inhibition of high levels of aggressive behavior due to alcohol consumption after anpirtoline treatment confirm the 5-HT1B receptor as a critical site in the termination of aggression.

Serotonin receptors and animal models of aggressive behavior.

A specific role for 5-HT1B receptor-subtype involvement in the modulation of aggression is delineated, with the restrictions the authors clearly face with regard to the lack of specific serotonergic agonists and antagonists for certain receptor subtypes.

Intruder-evoked aggression in isolated and nonisolated mice: Effects of psychomotor stimulants and l-Dopa

D-Amphetamine, methamphetamine, methylphenidate, cocaine, and l-dopa decreased attack and threat behavior by resident mice, the isolates requiring 2–4 times higher drug doses for the antiaggressive effects than the nonisolates.

EFFECTS OF DRUGS ON BEHAVIOUR OF AGGRESSIVE MICE

  • M. Kršiak
  • Biology, Psychology
    British journal of pharmacology
  • 1979
The inhibition of aggression induced by these drugs does not seem to be due to neuromuscular impairment and seems to this extent specific, and effects of the drugs on sociable activities in aggressive mice seem to correlate with their action on punished responding and other types of suppressed behaviour.

The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement

Experiments with delay of reinforcement in rats show that serotonergic mechanisms may be involved in this form of impulsive behaviour, which seems to support clinical findings in this area, and indicates that the procedure described here can be used to elucidate the pharmacological basis of this aspect ofImpulsive behaviour.

5-HT1B receptor knock out — behavioral consequences

...