Aggresome formation.

  title={Aggresome formation.},
  author={Michael J. Corboy and Philip J. Thomas and W. Christian Wigley},
  journal={Methods in molecular biology},
Bulk protein degradation in the cell is catalyzed by the ubiquitin-proteasome system (UPS). At the heart of the UPS is the proteasome, a large multisubunit tightly-regulated protease. The UPS performs key functions in protein quality control by monitoring and eliminating potentially toxic misfolded or damaged proteins. When the capacity of this protease… CONTINUE READING