Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system.
@article{Wang2004AggresomeFA, title={Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system.}, author={Liewei Wang and Vivien C. Yee and Richard M. Weinshilboum}, journal={Biochemical and biophysical research communications}, year={2004}, volume={325 2}, pages={ 426-33 } }
20 Citations
Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2005
It is observed that TPMT*3A forms aggresomes in cultured cells and that it aggregates in vitro, functional mechanisms not previously described in pharmacogenetics, which provide insight into a unique pharmacogenetic mechanism by which common polymorphisms affect T PMT protein function and, as a result, therapeutic response to thiopurine drugs.
Arylamine N-acetyltransferases
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NAT research in the past 5 years builds on that history and additionally paves the way for establishing new concepts in biology and opportunities in drug discovery.
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Identification and characterization of genetic variation in the folylpolyglutamate synthase gene.
- BiologyCancer research
- 2007
Observations suggest that genetic variations in FPGS may alter the efficacy of antifolate therapy in cancer patients as well as single nucleotide polymorphisms which exist in both the mitochondrial and cytosolic isoforms.
Pharmacogenomic Next-Generation DNA Sequencing: Lessons from the Identification and Functional Characterization of Variants of Unknown Significance in CYP2C9 and CYP2C19
- BiologyDrug Metabolism and Disposition
- 2019
High-throughput methods for pharmacogene variant mutagenesis and functional characterization of less-common open reading frame sequence variation might help to individualize therapy with drugs that are substrates for the enzymes encoded by these genes.
SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
- BiologyDrug Metabolism and Disposition
- 2021
Deep mutational scanning was applied to determine the functional effects of VUS that have been observed in the ORF of SLCO1B1, raising questions with regard to the application of DMS to intrinsic membrane proteins such as organic anion transporter protein 1B1.
CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants
- BiologyClinical and translational science
- 2020
DMS is supported as an efficient method for the identification of damaging ORF variants that might have potential clinical pharmacogenomic application after being adapted to study the function of missense variants in the open reading frames of cytochrome P450 family 2 subfamily C member 9 and CYP2C19.
SULT genetic polymorphisms: physiological, pharmacological and clinical implications
- BiologyExpert opinion on drug metabolism & toxicology
- 2021
The information concerning the differential sulfating activities of SULT allozymes toward endogenous compounds may allow for the development of strategies for mitigating anomalies in the metabolism of these endogenous compounds in individuals with certain SULT genotypes.
UDP Glucuronosyltransferase ( UGT ) 1 A 6 Pharmacogenetics : II . Functional Impact of the Three Most Common Nonsynonymous UGT 1 A 6 Polymorphisms ( S 7 A , T 181 A , and R 184 S )
- Biology
- 2005
There is substantial interindividual variability in the glucuronidation of UGT1A6 substrates by human liver that may have important pharmacological, toxicological, and physiological consequences and there is likely other genetic or environmental factors responsible for the majority of this variation.
Arylamine N-acetyltransferases
- Biology, Chemistry
- 2002
Transgenic mice are helping to unravel the endogenous role of human NAT1 that is widespread in tissues, expressed very early in development and overexpressed in estrogen-receptor-positive breast cancer.
References
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