Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide.

  title={Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide.},
  author={David R. Howlett and K. H. Jennings and David A Lee and Michelle P. Clark and Fred L. Brown and Roxane Wetzel and Stephen J. Wood and Patrick Camilleri and Gareth W Roberts},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  volume={4 1},
The behaviour of synthetic batches of beta-amyloid (beta A) 1-40 peptide in solution has been studied. The effects of beta A1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the peptide before application to the cells. Fibrillization of the beta A1-40, quantitatively assessed by the binding of Congo red to amyloid fibrils, also increased in a time dependent manner over the 168 h incubation period studied. The degree of Congo red binding… CONTINUE READING


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