Aggregation of rhDNase Occurred During the Compression of KBr Pellets Used for FTIR Spectroscopy

Abstract

Purpose. To determine if a protein changes when it is compressed into a KBr pellet for FTIR spectroscopy measurement in the solid state, using recombinant human deoxyribonuclease I (rhDNase) as an example. Methods. Lyophilized rhDNase with KBr compressed at different pressures were analyzed by FTIR spectroscopy, size exclusion HPLC and enzymatic activity… (More)
DOI: 10.1023/A:1016091030928

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