Aggregation of recombinant human growth hormone induced by phenolic compounds

@inproceedings{Maa1996AggregationOR,
  title={Aggregation of recombinant human growth hormone induced by phenolic compounds},
  author={Yuh-Fun Maa and Chung C. Hsu},
  year={1996}
}
Abstract Phenolic compounds can be used as antimicrobial preservative agents in pharmaceutical formulations. Unfortunately, these compounds often adversely affect proteins, triggering aggregation in particular. In this study, a variety of phenolic compounds and structurally similar non-aromatic alcohols were investigated for their role in causing the aggregation of a model therapeutic protein, recombinant human growth hormone (rhGH). As determined by various methodologies, most of the phenolic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS