Aggregation of porcine pancreatic phospholipase A2 and Its zymogen induced by submicellar concentrations of negatively charged detergents.


The interaction of two sodium n-alkyl sulfates (C10 and C12) with porcine pancreatic phospholipase A2 and its zymogen was studied by various spectroscopic techniques, equilibrium gel filtration, calorimetry, and photochemically induced dynamic nuclear polarization 1H NMR. At very low concentrations of n-alkyl sulfate [up to 0.07 X critical micelle… (More)


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