Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties.

@article{Bartosh2010AggregationOH,
  title={Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties.},
  author={Thomas J. Bartosh and Joni H Yl{\"o}stalo and Arezoo Mohammadipoor and Nikolay Bazhanov and Katie Coble and Kent Claypool and Ryang Hwa Lee and Hosoon Choi and D. J. Prockop},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 31},
  pages={13724-9}
}
Previous reports suggested that culture as 3D aggregates or as spheroids can increase the therapeutic potential of the adult stem/progenitor cells referred to as mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs). Here we used a hanging drop protocol to prepare human MSCs (hMSCs) as spheroids that maximally expressed TNFalpha stimulated gene/protein 6 (TSG-6), the antiinflammatory protein that was expressed at high levels by hMSCs trapped in the lung after i.v. infusion and… CONTINUE READING
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