Aggregation of human and canine platelets: modulation by purine nucleotides.

@article{Soslau1993AggregationOH,
  title={Aggregation of human and canine platelets: modulation by purine nucleotides.},
  author={Gerald Soslau and L Arabe and Jody Parker and Amir Pelleg},
  journal={Thrombosis research},
  year={1993},
  volume={72 2},
  pages={127-37}
}
This study compared the responses of canine and human platelets to various aggregating agonists in the presence or absence of extracellular ATP and ATP analogues. Canine and human platelets were approximately equally reactive with ADP or collagen while the canine platelets were about 10 fold more sensitive to thrombin. Canine platelets were insensitive to the thromboxane mimetic U46619 but were synergistically aggregated by a mixture of ADP and U46619. Human platelets were very sensitive to… CONTINUE READING