Aggregation of chromaffin granules by calpactin at micromolar levels of calcium

@article{Drust1988AggregationOC,
  title={Aggregation of chromaffin granules by calpactin at micromolar levels of calcium},
  author={Debra S. Drust and Carl E. Creutz},
  journal={Nature},
  year={1988},
  volume={331},
  pages={88-91}
}
Several cytosolic proteins bind to secretory granule membranes in a Ca2+-dependent manner and thus may be involved in the mediation of membrane interactions during exocytosis1,2. One of these proteins3, calpactin, is a tetramer consisting of two heavy chains of relative molecular mass (Mr) 36K (p36) and two light chains of 10K (p10)4,5. We report here that calpactin promotes the Ca2+-dependent aggregation and fatty acid-dependent fusion of chromaffin granule membranes at a level of Ca2+ that is… CONTINUE READING

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