Aggregation of MHC class I molecules on a CD8+ alphabeta T cell clone specifically inhibits non-antigen-specific lysis of target cells.

@article{Caparrs2004AggregationOM,
  title={Aggregation of MHC class I molecules on a CD8+ alphabeta T cell clone specifically inhibits non-antigen-specific lysis of target cells.},
  author={Esther Caparr{\'o}s and Agust{\'i}n Beltr{\'a}n De Heredia and Emilio Carpio and David de Sancho and Enrique Fern{\'a}ndez Aguado and Pedro Apar{\'i}cio},
  journal={European journal of immunology},
  year={2004},
  volume={34 1},
  pages={47-55}
}
MHC class I molecules are target molecules recognized by TCR or NK receptors encoded in the NK gene cluster or leukocyte receptor cluster. We show that aggregation of MHC class I molecules by specific monoclonal antibodies on cytotoxic T cells, inhibits the anti-CD94 redirected lysis of P815. This inhibition is not the consequence of apoptosis or anergy of the cytotoxic T lymphocytes. In contrast, aggregation of MHC class I molecules does not inhibit either the anti-CD3 redirected cytotoxicity… CONTINUE READING