Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

@inproceedings{RombachRiegraf2014AggregationOH,
  title={Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro},
  author={Verena Rombach-Riegraf and Anette C. Karle and Babette Wolf and Laetitia Sord{\'e} and Stephan Koepke and Sascha Gottlieb and Jennifer Krieg and Marie-Claude Djidja and Aida Baban and Sebastian Spindeldreher and Atanas V. Koulov and Andrea Kiessling},
  booktitle={PloS one},
  year={2014}
}
Subvisible proteinaceous particles which are present in all therapeutic protein formulations are in the focus of intense discussions between health authorities, academics and biopharmaceutical companies in the context of concerns that such particles could promote unwanted immunogenicity via anti-drug antibody formation. In order to provide further understanding of the subject, this study closely examines the specific biological effects proteinaceous particles may exert on dendritic cells (DCs… CONTINUE READING
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