Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine

@article{Burke2007AggregationO,
  title={Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine},
  author={William Joseph Burke and V. Bharath Kumar and Neeraj Pandey and Whitney M. Panneton and Qi Gan and Mark W. Franko and Mark A. O’Dell and Shu Wen Li and Yi Pan and Hyung D. Chung and James E. Galvin},
  journal={Acta Neuropathologica},
  year={2007},
  volume={115},
  pages={193-203}
}
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons and the presence of α-synuclein (AS) aggregates as Lewy bodies (LBs) in the remaining substantia nigra (SN) neurons. A continuing puzzle in studying PD pathogenesis is that although AS is expressed throughout the brain, LBs and selective dopaminergic cell loss lead to characteristic clinical signs of PD, suggesting that there is a link between AS aggregation and DA metabolism… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

  • The Journal of clinical investigation
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Dihydroxyphenylacetaldehyde potentiates the toxic eVects of metabolic stress in PC 12 cells

I Lamensdorf, G Eisenhofer, +3 authors IJ Kopin
  • Brain Res
  • 2000
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Dopaminedependent neurotoxicity of -synuclein: a mechanism for selective neurodegeneration in Parkinson’s disease

J Xu, SY Kao, W Song, LW Jin, BA Yankner
  • Nat Med
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…