Aggregation kinetics of bovine serum albumin studied by FTIR spectroscopy and light scattering.

@article{Militello2004AggregationKO,
  title={Aggregation kinetics of bovine serum albumin studied by FTIR spectroscopy and light scattering.},
  author={Valeria Militello and Carlo Casarino and Antonio Emanuele and Antonella Giostra and Filippo Pullara and Maurizio Leone},
  journal={Biophysical chemistry},
  year={2004},
  volume={107 2},
  pages={175-87}
}
To investigate which type of structural and conformational changes is involved in the aggregation processes of bovine serum albumin (BSA), we have performed thermal aggregation kinetics in D(2)O solutions of this protein. The tertiary conformational changes are followed by Amide II band, the secondary structural changes and the formation of beta-aggregates by the Amide I' band and, finally, the hydrodynamic radius of aggregates by dynamic light scattering. The results show, as a function of pD… CONTINUE READING
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