Aggregation factor analysis for protein formulation by a systematic approach using FTIR, SEC and design of experiments techniques.

Abstract

A simple systematic approach using Fourier transform infrared (FTIR) spectroscopy, size exclusion chromatography (SEC) and design of experiments (DOE) techniques was applied to the analysis of aggregation factors for protein formulations in stress and accelerated testings. FTIR and SEC were used to evaluate protein conformational and storage stabilities… (More)
DOI: 10.1016/j.jpba.2011.08.035

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