Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.

@article{Silvers2017AggregationAF,
  title={Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.},
  author={Robert Silvers and Michael T. Colvin and Kendra King Frederick and Angela C. Jacavone and Susan L. Lindquist and Sara Linse and Robert G Griffin},
  journal={Biochemistry},
  year={2017},
  volume={56 36},
  pages={
          4850-4859
        }
}
A mechanistic understanding of Aβ aggregation and high-resolution structures of Aβ fibrils and oligomers are vital to elucidating relevant details of neurodegeneration in Alzheimer's disease, which will facilitate the rational design of diagnostic and therapeutic protocols. The most detailed and reproducible insights into structure and kinetics have been achieved using Aβ peptides produced by recombinant expression, which results in an additional methionine at the N-terminus. While the length… CONTINUE READING

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