Aggregation Analysis of Therapeutic Proteins , Part 1 General Aspects and Techniques for Assessment

@inproceedings{Arakawa2006AggregationAO,
  title={Aggregation Analysis of Therapeutic Proteins , Part 1 General Aspects and Techniques for Assessment},
  author={Tsutomu Arakawa and Daisuke Ejima and Kouhei Tsumoto},
  year={2006}
}
stable in solution, undergoing conformational changes due to various stresses during purification, processing and storage. Such stresses can include elevated temperature, shear strain, surface adsorption, and high protein concentration (1). Structurally altered proteins have a strong tendency to aggregate, often leading to eventual precipitation (2). Irreversible aggregation is a major problem for long-term storage stability of therapeutic proteins and for their shipping and handling… CONTINUE READING

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