Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice.

@article{Zhang2010AggregatibacterAA,
  title={Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice.},
  author={Tao Zhang and Tomoko Kurita-Ochiai and Tomomi Hashizume and Yuan Du and Sumito Oguchi and Masafumi Yamamoto},
  journal={FEMS immunology and medical microbiology},
  year={2010},
  volume={59 2},
  pages={143-51}
}
Cariogenic and periodontal pathogens are thought to be etiological factors in the development of cardiovascular disease. We assessed the involvement of the periodontal pathogen Aggregatibacter actinomycetemcomitans and cariogenic pathogen Streptococcus mutans in the development of atherosclerosis in apolipoprotein E-deficient spontaneously hyperlipidemic (Apoe(shl)) mice. The mice were treated intravenously with A. actinomycetemcomitans HK1651, S. mutans GS-5, or phosphate-buffered saline three… CONTINUE READING

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