Aggregated IgG inhibits the differentiation of human fibrocytes.

  title={Aggregated IgG inhibits the differentiation of human fibrocytes.},
  author={Darrell Pilling and Nancy M Tucker and Richard H Gomer},
  journal={Journal of leukocyte biology},
  volume={79 6},
Fibrocytes are fibroblast-like cells, which appear to participate in wound healing and are present in pathological lesions associated with asthma, pulmonary fibrosis, and scleroderma. Fibrocytes differentiate from CD14+ peripheral blood monocytes, and the presence of serum delays this process dramatically. We previously purified the factor in serum, which inhibits fibrocyte differentiation, and identified it as serum amyloid P (SAP). As SAP binds to Fc receptors for immunoglobulin G (IgG; Fc… CONTINUE READING
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