Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.

@article{Struglics2012AggrecanaseCI,
  title={Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.},
  author={Andr{\'e} Struglics and L Stefan Lohmander and Karena Last and Jonathan D. Akikusa and Roger Allen and Amanda J Fosang},
  journal={Arthritis and rheumatism},
  year={2012},
  volume={64 12},
  pages={4151-61; author reply 4162-3}
}
OBJECTIVE To investigate aggrecan degradation in juvenile idiopathic arthritis (JIA). METHODS The pattern and abundance of aggrecan fragments in synovial fluid (SF) aspirates from JIA patients were analyzed and compared with aggrecan fragments in SF from patients with other arthritides, children with knee injury, and a knee-healthy reference group. Concentrations of sulfated glycosaminoglycan (sGAG) in SF were measured by Alcian blue precipitation assay. Aggrecan fragments were purified by… CONTINUE READING