Aggrecan domains expected to traffic through the exocytic pathway are misdirected to the nucleus.

@article{Chen2001AggrecanDE,
  title={Aggrecan domains expected to traffic through the exocytic pathway are misdirected to the nucleus.},
  author={T L Chen and Pei Yin Wang and Wei Zhen Luo and S S Gwon and N W Flay and J. S. Zheng and Chunbao Guo and Marvin L. Tanzer and Barbara M. Vertel},
  journal={Experimental cell research},
  year={2001},
  volume={263 2},
  pages={224-35}
}
In this article, we report the misdirected targeting of expressed aggrecan domains. Aggrecan, the chondroitin sulfate (CS) proteoglycan of cartilage, normally progresses through the exocytic pathway. Proteins expressed from constructs containing the putative aggrecan signal sequence (i.e., the first 23 N-terminal amino acids), specified globular (G) domains… CONTINUE READING