Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

@article{Lark1997AggrecanDI,
  title={Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.},
  author={Michael W. Lark and Ellen K. Bayne and Jean Flanagan and Caroline Harper and L A Hoerrner and N I Hutchinson and Irwin I. Singer and S A Donatelli and Jeffrey R. Weidner and Hollis R. Williams and Richard A. Mumford and L Stefan Lohmander},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 1},
  pages={93-106}
}
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in VDIPEN341 were compared with the distribution of aggrecanase… CONTINUE READING