Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system

@inproceedings{Sato2017AggravationOC,
  title={Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system},
  author={Keisuke Sato and Naoki Takahashi and Tamotsu Kato and Yumi Matsuda and Mai Yokoji and Miki Yamada and Takako Eguchi Nakajima and Naoki Kondo and Naoto Endo and Reiko Yamamoto and Yuichiro Noiri and Hiroshi Ohno and Kazuhisa Yamazaki},
  booktitle={Scientific Reports},
  year={2017}
}
Porhyromonas gingivalis, a causative bacterium of periodontitis, is implicated in the etiology of rheumatoid arthritis (RA), mainly because of expressing peptidyl arginine deiminase (PAD) that generates RA-related autoantigens. However, compared with other periodontopathic bacteria, the precise role of P. gingivalis in RA is largely unknown. We found that orally administered P. gingivalis changed the gut microbiome with concomitant elevation of serum endotoxin and inflammatory markers, and… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 64 references

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

  • J Chen
  • Genome Med
  • 2016

Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver

  • M Nakajima
  • PLoS One 10,
  • 2015

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