Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats

@article{Okayama2006AggravationBS,
  title={Aggravation by Selective COX-1 and COX-2 Inhibitors of Dextran Sulfate Sodium (DSS)-Induced Colon Lesions in Rats},
  author={Mitsuaki Okayama and Shusaku Hayashi and Yoko Aoi and Hikaru Nishio and Shinichi Kato and Koji Takeuchi},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={2095-2103}
}
We examined the effect of cyclooxygenase (COX) inhibitors on dextran sulfate sodium (DSS)-induced ulcerative colitis in rats and investigated the role of COX isozymes in the pathogenesis of this model. Experimental colitis was induced by treatment with 2.5% DSS in drinking water for 6 days. Indomethacin (a nonselective COX inhibitor), SC-560 (a selective COX-1 inhibitor), or celecoxib (a selective COX-2 inhibitor) was given PO twice daily for 6 days, during the first 3 or last 3 days of the… CONTINUE READING
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