Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice

@article{SHI2012AggravatedIA,
  title={Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice},
  author={Wen-zhen SHI and Chun-zhen Zhao and Bing Zhao and Qiao-juan Shi and Lihui Zhang and Yanfang Wang and San-hua Fang and Yun-bi Lu and Wei-ping Zhang and Er-qing Wei},
  journal={Neuroscience Bulletin},
  year={2012},
  volume={28},
  pages={680-692}
}
Aquaporin-4 (AQP4), the main water channel protein in the brain, plays a critical role in water homeostasis and brain edema. Here, we investigated its role in the inflammatory responses after focal cerebral ischemia. In AQP4-knockout (KO) and wild-type mice, focal cerebral ischemia was induced by 30 min of middle cerebral arterial occlusion (MCAO). Ischemic neuronal injury and cellular inflammatory responses, as well as the expression and localization of cysteinyl leukotriene CysLT2 and CysLT1… CONTINUE READING

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