Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent.

@article{Salehi1998AggravatedDI,
  title={Aggravated decrease in the activity of nucleus basalis neurons in Alzheimer's disease is apolipoprotein E-type dependent.},
  author={Ahmad Salehi and Elisabeth J G Dubelaar and Monique Mulder and Dick F. Swaab},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 19},
  pages={11445-9}
}
As reported before, the metabolic activity of nucleus basalis neurons is reduced significantly in Alzheimer patients. Because the apolipoprotein E (ApoE) epsilon4 genotype is a major risk factor for Alzheimer's disease (AD), we determined whether the decrease in metabolic activity in nucleus basalis neurons in AD is ApoE-type dependent. The size of the Golgi apparatus (GA) was determined as a measure of neuronal metabolic activity in 30 controls and 41 AD patients with a known ApoE genotype by… CONTINUE READING
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