Agglutination of Pseudomonas aeruginosa by surfactant protein D.

  title={Agglutination of Pseudomonas aeruginosa by surfactant protein D.},
  author={Matthias Griese and Vitaliy Starosta},
  journal={Pediatric pulmonology},
  volume={40 5},
Surfactant protein D (SP-D) is part of the innate host defense system, and may bind and agglutinate invading microorganisms to enhance their removal. The ability of bronchoalveolar lavage (BAL) fluid to agglutinate bacteria and the relationship to its SP-D content are of interest and not yet known. A micromethod on slides was used to assess the agglutination of Pseudomonas aeruginosa by recombinant SP-D and native human BAL fluid. The SP-D-induced agglutination was blocked by calcium depletion… CONTINUE READING