Agglomerative epigenetic aberrations are a common event in human breast cancer.

@article{Novk2008AgglomerativeEA,
  title={Agglomerative epigenetic aberrations are a common event in human breast cancer.},
  author={Petr Nov{\'a}k and Taylor Jensen and Marc M. Oshiro and George S. Watts and Christina J. Kim and Bernard W. Futscher},
  journal={Cancer research},
  year={2008},
  volume={68 20},
  pages={8616-25}
}
Changes in DNA methylation patterns are a common characteristic of cancer cells. Recent studies suggest that DNA methylation affects not only discrete genes, but it can also affect large chromosomal regions, potentially leading to LRES. It is unclear whether such long-range epigenetic events are relatively rare or frequent occurrences in cancer. Here, we use a high-resolution promoter tiling array approach to analyze DNA methylation in breast cancer specimens and normal breast tissue to address… CONTINUE READING

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