Agents that target telomerase and telomeres.

@article{Raymond1996AgentsTT,
  title={Agents that target telomerase and telomeres.},
  author={Eric Raymond and Dantong Sun and Su Feng Chen and Brad Windle and Daniel Von Hoff},
  journal={Current opinion in biotechnology},
  year={1996},
  volume={7 6},
  pages={583-91}
}
Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be expressed in tumor cells, which concurrently have short telomeres, and not in most somatic cells, which usually have long telomeres, telomerase and telomere structures have been recently proposed as… CONTINUE READING

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