Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair.

@article{Sreevidya2010AgentsTR,
  title={Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair.},
  author={Coimbatore S. Sreevidya and Atsushi Fukunaga and Noor Mohammad Khaskhely and Taro Masaki and Ryusuke Ono and Chikako Nishigori and Stephen E. Ullrich},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 5},
  pages={1428-37}
}
UV exposure induces skin cancer, in part, by inducing immune suppression. Repairing DNA damage, neutralizing the activity of cis-urocanic acid, and reversing oxidative stress abrogate UV-induced immune suppression and skin cancer induction, suggesting that DNA, UCA, and lipid photo-oxidation serve as UV photoreceptors. What is not clear is whether signaling through each of these different photoreceptors activates independent pathways to induce biological effects or whether there is a common… CONTINUE READING

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The role of glutathione in the regulation of nucleotide excision repair during oxidative stress

  • Langie SAS, AM Knaapen, Houben JMJ, FC Kempen, Hoon JPJ, Gottschalk RWH
  • Toxicol Lett
  • 2007

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