Agents in Development for the Management of Cocaine Abuse

@article{Gorelick2004AgentsID,
  title={Agents in Development for the Management of Cocaine Abuse},
  author={Dr David A. Gorelick and Eliot L. Gardner and Zheng-Xiong Xi},
  journal={Drugs},
  year={2004},
  volume={64},
  pages={1547-1573}
}
Cocaine abuse is a serious health problem in many areas of the world, yet there are no proven effective medications for the treatment of cocaine dependence. Preclinical studies suggest that the reinforcing effect of cocaine that promotes its abuse is mediated by blockade of the presynaptic dopamine transporter. This results in increased dopamine activity in the mesolimbic or meso-accumbens dopamine reward system of brain. Development of new medications to treat cocaine dependence has focused on… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
57 Extracted Citations
143 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 57 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 143 references

Efficacy of disulfiram among addicts from a community clinic sample

  • WN Raby, S Coomaraswamy, KM Carroll, LR Fenton, SA Ball
  • J Clin Psychi - and cognitive behavior therapy in…
  • 2004

Jan 15 [Epub ahead of print] place preference in rats

  • PJ Kenny, NE Paterson, B Boutrel
  • Psychopharmacology (Berl)
  • 2004

The neurobiology and genetics of addiction: impli2004

  • EL Gardner
  • 2004

Transdermal selegiline neuroanatomy of corticotropin - releasing factor

  • GF Koob, SC Heinrichs, A Montgomery, A Elkashef, DA Ciraulo
  • 2004

update of factor and urocortin in behavioral responses to stressors

  • GF Koob, SC Heinrichs, A Montgomery, A Elkashef, DA Ciraulo
  • Brain NIDA phase II medications development…
  • 2004

A novel strategy for Neurosci

  • SL Dewey, AE Morgan, CR Ashby
  • 2003

A role for corticotropin-releasing

  • GF BalHarbour161.Koob, SC Heinrichs
  • 2003

Similar Papers

Loading similar papers…