Agents in Development for the Management of Cocaine Abuse

  title={Agents in Development for the Management of Cocaine Abuse},
  author={Dr David A. Gorelick and Eliot L. Gardner and Zheng-Xiong Xi},
Cocaine abuse is a serious health problem in many areas of the world, yet there are no proven effective medications for the treatment of cocaine dependence. Preclinical studies suggest that the reinforcing effect of cocaine that promotes its abuse is mediated by blockade of the presynaptic dopamine transporter. This results in increased dopamine activity in the mesolimbic or meso-accumbens dopamine reward system of brain. Development of new medications to treat cocaine dependence has focused on… CONTINUE READING
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