Agents affecting osteolysis in patients with breast cancer

@article{Coombes2004AgentsAO,
  title={Agents affecting osteolysis in patients with breast cancer},
  author={R. C. Coombes and A. Neville and J. Gazet and H. T. Ford and A. G. Nash and J. W. Baker and T. Powles},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={3},
  pages={41-44}
}
  • R. C. Coombes, A. Neville, +4 authors T. Powles
  • Published 2004
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • SummaryAspirin and indomethacin, flurbiprofen, synthetic human calcitonin, and mithramycin were assessed for their anti-osteolytic properties in patients with breast cancer and painful skeletal metastases.Some patients responded with pain relief to aspirin/indomethacin (2/10), flurbiprofen (2/9), calcitonin (2/7), and mithramycin (3/8). Objective evidence of reduction of osteolysis occurred with flurbiprofen, mithramycin, and calcitonin, but not with aspirin and indomethacin. A sustained… CONTINUE READING

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